A driver from Philadelphia was seriously hurt in the crash, according to New Jersey State Police.
Troopers responded to the crash at about 6 a.m. at Interchange 4 in Mount Laurel Township.
Based on a preliminary investigation, a Mack tractor-trailer operated by a 59-year-old Philadelphia man was traveling northbound on the Turnpike and was negotiating a curve of the entrance ramp at milepost 34.6, State Police said.
That's when the truck overturned and the driver was seriously injured.
The crash remains under investigation.
Click here to follow Daily Voice West Chester and receive free news updates.